Research Investigator, Orthopaedic Surgery

Bone structure/function, primarily at the cellular and bone tissue level; whether and how bone cells sense bone mechanics; computational bone mechanics at multiple hierarchical levels; occupant injury in automobile crashes

EDUCATION

1988-92 Case Western Reserve University, Cleveland, Ohio; B.S. Mechanical Engineering

1992-94 University of Michigan, Ann Arbor, Michigan; M.S., Bioengineering

1992-94 University of Michigan, Ann Arbor, Michigan; M.S.E., Mechanical Engineering

1994-00 University of Michigan, Ann Arbor, Michigan; Ph.D., Biomedical Engineering

PUBLICATIONS

Peer-Reviewed Publications

l. McCreadie BR, Goldstein SA: Biomechanics of fracture: Is BMD sufficient to asses risk? (editorial). Journal of Bone and Mineral Research 15:2305-2308, 2000.

2. McCreadie BR, Hollister SJ: Strain concentrations surrounding an ellipsoid model of lacunae and osteocytes. Computer Methods in Biomechanics and Biomedical Engineering 1:61-68, 1997.

3. Hollister SJ, Riemer BA: Digital-image-based finite element analysis for bone microstructure using conjugate gradient and Gaussian filter techniques, Proc. SPIE 2035:95-106, 1993.

Submitted for Publication

1. McCreadie BR, Champion JA, Goldstein SA: Trabecular bone tissue mineral content in osteoporotic and normal women.

Manuscripts in Preparation

1. McCreadie BR, Schaffler MB, Goldstein SA: Osteocyte lacuna size and shape in osteoporotic and normal females.

2. McCreadie BR, Goldstein SA, Hollister SJ: Fluid flow and deformation in and around the osteocyte, calculated with fluid-solid homogenization and poroelasticity.

Chapters in Books

1. Hoffler CE, McCreadie BR, Smith EA, Goldstein SA: A hierarchical approach to exploring bone mechanical properties. In Mechanical testing of bone and the bone-implant environment, ed: An YH and Draughn RA. CRC Press, Boca Raton, 2000.
2. McCreadie BR, Goulet RW, Feldkamp LA, Goldstein SA: Hierarchical structure of bone and micro-computed tomography. In Non-invasive Assessment of Trabecular Bone Architecture and the Competence of Bone, ed: Sharmila Majumdar and Brian K. Bay. Kluwer Academic / Plenum Publishers, New York, in press.

Abstracts

1. McCreadie BR, Goldstein SA, Hollister SJ: Strains and fluid flow in and surrounding the osteocyte calculaed with poroelasticity and fluid-solid homogenization. ORS 47th Annual Meeting, February 25-28, 2001.
2. McCreadie BR, Goldstein SA: Quantitative Measurement of Osteocyte Lacuna Size and Shape from Osteoporotic and Normal Individuals from Confocal Microscopy Images. ORS 46th Annual Meeting, March 12-15, 2000.
3. McCreadie BR, Hollister SJ: Confocal microscopy based digital finite element analysis of local strains in and around in situ osteocytes. ORS 45th Annual Meeting, February 1-4, 1999.
4. Riemer BA, Eadie JS, Wenzel TE, Weissman DE, Guo XE, Goldstein SA: Microstructure and material property variations in compact and trabecular vertebral bone tissue. Trans ORS 20(2): 529, 1995.
5. Riemer BA, Hollister SJ: Analysis of osteocyte and lacunar strains using an idealized finite element model. Trans ORS 20(2): 540, 1995.
6. Eadie JS, Riemer BA, Goldstein SA: Quantification of vertebral trabecular bone tissue microstructure. Trans ORS 20(20): 528, 1995
7. Riemer BA, Eadie JS, Weissman DE, Haut KM, Hollister SJ, Goldstein SA: Characterization of the architecture, tissue properties, and continuum behavior of aging trabecular bone. Trans ORS 19(1): 189, 1994.
8. Riemer BA, Hollister SJ: An analysis of strains surrounding lacunae and canaliculi. 18th Annual Meeting, American Society of Biomechanics, p. 167-168, October 13-15, 1994.