Research

The Architecture project group encompasses a large variety of research projects, dealing with the study of bone properties at multiple hierarchical levels, and determining the effects of medical devices on orthopaedic problems. The common theme among these projects is to apply engineering concepts or an engineering approach to studying bone or bone/medical device constructs. The biological specimens range from human tissue (autopsy and surgical specimens), to normal animals, to genetically altered animals, and experiments are conducted at all levels of hierarchy, ranging from the lamellar levels to the whole organ of bone.

View abstracts from the Architecture project group below.

AGE EFFECTS ON THE FATIGUE BEHAVIOR OF HUMAN VERTEBRAL CANCELLOUS TISSUE T.E. Ciarelli, M.B. Schaffler, S.A. Goldstein

ANALYSIS OF THE SKELETAL TRAITS OF THE ESTROGEN RECEPTOR (ALPHA) DEFICIENT MOUSE K.M. Kozloff, M. Spurchise, E.P. Frankenburg, S.A. Goldstein, L. McCauley

COMPARISON OF SCANNING ACOUSTIC MICROSCOPY AND NANOINDENTATION MEASURES OF THE ELASTIC PROPERTIES OF HUMAN BONE LAMELLAE C. E. Hoffler, N. Zhang, K. M. Kozloff, M. J. Grimm, S. A. Goldstein

CONFOCAL MICROSCOPY BASED DIGITAL FINITE ELEMENT ANALYSIS OF LOCAL STRAINS IN AND AROUND IN SITU OSTEOCYTES B.R. McCreadie, S.J. Hollister

EFFECTS OF ANATOMICAL LOCATION, AGE, GENDER, BODY MASS, HEIGHT AND BODY MASS INDEX ON ELASTIC MODULUS OF HUMAN BONE TISSUE LAMELLAE C. E. Hoffler, K. M. Kozloff, K. E. Moore, M. T. Dillon, M. Brown, W. Pan, P. K. Zysset, S. A. Goldstein

EFFECT OF LONG TERM ADMINISTRATION OF VITAMIN D3 ANALOGS ON MICE E.A. Smith, E.P. Frankenburg, P. Koeffler, S.A. Goldstein

EFFECT OF VITAMIN D3 METABOLITES ON BONE INTEGRITY E.A. Smith, E.P. Frankenburg, S.K. Volkman, A. Norman, S.A. Goldstein

FLUID-SOLID HOMOGENIZATION OF BONE TISSUE AT THE CANALICULAR CHANNEL AND CELLULAR LEVELS B.R. McCreadie, S.A. Goldstein, S.J. Hollister

GENETICS OF AGE-SENSITIVE SKELETAL TRAITS IN HETEROGENEOUS MICE S. Volkman, C.R. Maynard, S.A. Goldstein, M.R. Moalli, R. Miller, D. T. Burke, A. Galecki, D.C. Kayner, M.W. Stock

MECHANICAL AND GEOMETRIC CHARACTERISTICS OF BONE IN BIGLYCAN DEFICIENT MICE T. Adachi, E.A. Smith, K. Kozloff, M. Young, S.A. Goldstein

MECHANICAL AND GEOMETRIC CHARACTERISTICS OF BONE IN THROMBOSPONDIN2 DEFICIENT MICE E.A. Smith, S.A. Goldstein, J. Bonadio

MECHANICAL PROPERTIES OF VERTEBRA IN BIGLYCAN DEFICIENT MICE T. Adachi, M. Young, P. Gehron Robey, X.-D. Chen, M. Moalli, S. A. Goldstein

MINERAL QUANTIFICATION IN OSTEOPOROTIC AND NORMAL WOMEN B.R. McCreadie, J. Champion, S.A. Goldstein

A NEW TRANSGENIC MOUSE MODEL FOR OSTEOGENESIS IMPERFECTA E.P. Frankenburg, K.M. Kozloff, M.W. Stock, D.C. Kayner, A. Furling, C. Bergwitz, J.C. Marini, S.A. Goldstein

QUANTITATIVE MEASUREMENT OF OSTEOCYTE LACUNA SIZE AND SHAPE FROM FRACTURED AND NORMAL INDIVIDUALS FROM CONFOCAL MICROSCOPY IMAGES B.R. McCreadie, M. Schaffler, S.A. Goldstein

TRABECULAR SURFACE REMODELING SIMULATION USING MICROSTRUCTURAL FINITE ELEMENT MODELS T. Adachi, K. Tsubota*, Y. Tomita*, N. J. Caldwell, S. J. Hollister,